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October 19, 2025Open Access

Cumulative Joint Burden of Functional Limitation and Depressive Symptoms on Cardiovascular Disease Risk ：A Nationwide Bidirectional Mediation and Competing Risks Analysis

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Authors

CLChuyi LuoCWChun WangCJChunhui Jiang

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Overview

Analysis reveals cumulative effects of functional limitation and depressive symptoms on cardiovascular disease, suggesting integrated health strategies.

Key Points

  • The co-occurrence of functional limitation and depressive symptoms significantly increases cardiovascular disease risk.
  • Over a median follow-up of 7 years, 2,294 participants developed cardiovascular disease, highlighting a serious health issue.
  • Bidirectional mediation analysis demonstrated that depressive symptoms mediate a portion of the functional limitation effect on cardiovascular disease.
  • Integrated strategies targeting both functional and mental health may be necessary to reduce cardiovascular disease burden.

Cite This Study

Luo et al. (2025) studied this question.

synapsesocial.com/papers/68f43ef4854d1061a58abb97https://doi.org/10.21203/rs.3.rs-7509404/v1
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