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July 14, 2025

Dynamic Interactions Among Activities of Daily Living, Depressive Symptoms, and Incident Cardiovascular Disease in Chinese Adults Aged 45 and Older: A 7-Year Longitudinal Study

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Authors

CLC. L. LuoCJChunhui JiangYDYan‐Jun Du

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Overview

Longitudinal study shows depressive symptoms and ADL impairments increase cardiovascular disease risk in older Chinese adults, suggesting integrated interventions may help.

Key Points

  • In a cohort of 4,356 Chinese adults aged ≥ 45, 15.5% developed cardiovascular disease (CVD) over 7 years.
  • Each one-point increase in cumulative CES-D score was associated with a 4% higher CVD risk, while a similar increase in ADL score indicated a 14% higher risk.
  • Causal mediation analysis indicated that ADL impairment mediated 26.1% of the depression–CVD link and vice versa at 37.9%.
  • Joint effects of depressive symptoms and ADL impairment on CVD exhibited sub-additive interaction, highlighting complexity in their relationship.

Cite This Study

Luo et al. (2025) studied this question.

synapsesocial.com/papers/689a02afe6551bb0af8cc1b6https://doi.org/10.21203/rs.3.rs-6808275/v1
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Association of depression, physical functioning and incident cardiovascular disease: a national cohort study2025
  2. 2Dose-response relationship between cumulative average depressive symptoms and cardiovascular disease incidence in middle-aged and older Chinese adults: A 7-year prospective cohort study2025
  3. 3Cumulative Joint Burden of Functional Limitation and Depressive Symptoms on Cardiovascular Disease Risk ：A Nationwide Bidirectional Mediation and Competing Risks Analysis2025
  4. 4The longitudinal bidirectional association between cardiovascular disease and depressive symptoms among middle-aged and elderly adults: evidence from a nationwide cohort study in China2025 · 3 citations
  5. 5Bidirectional association between depressive symptoms and cardiovascular disease in the middle-aged and elderly Chinese: a 5-year longitudinal study2023 · 24 citations