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August 8, 2022Frontiers in PsychiatryOpen Access

Depressive symptoms linked to ~54% higher risk of incident ADL disability.

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Why the study?

Activities of daily living disability is a concern in the aging population and the associations of chronic conditions and depressive symptoms with ADL disability were assessed.

Do chronic diseases and depressive symptoms increase the risk of incident ADL disability in middle-aged and older adults?

Population

10,864 participants aged 45 and older from China

Comparison

Presence vs absence of chronic diseases and depressive symptoms

Design

Prospective population-based cohort study

Follow-up

4 years

Key result

The presence of depressive symptoms was independently associated with a 54% increased risk of incident ADL disability (HR 1.54) compared to those without depressive symptoms.

Authors

YHYingyun HuFZFeixiang ZhouAKAtipatsa Chiwanda Kaminga

Discussion

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Member takes

Overview

Depressive symptoms may flag elevated ADL disability risk in middle-aged adults; extends prior associations but leaves causality and intervention effects open.

Study Design

Type

Cohort (n=10,864)

Multicenter

Yes

Structured PICO

Do chronic diseases and depressive symptoms increase the risk of incident ADL disability in middle-aged and older adults?

P
Population
10,864 middle-aged and older adults in China (mean age 58.1 years, 50.9% female), free of baseline disabilities, followed for 4 years to assess incident ADL disability.
E
Exposure
Presence of at least one chronic disease and/or depressive symptoms
C
Comparator
Absence of chronic disease and/or depressive symptoms
O
Outcome
Incident ADL disability assessed using the Katz ADL scalespatient reported

Main Result

Hazard Ratio: 1.54 (95% CI 1.3–1.82)

Absolute Event Rate: 28.48% vs 13.7%

Chronic diseases and depressive symptoms are independently associated with an increased risk of ADL disability in middle-aged and older Chinese adults.

Limitations

  • Potential recall bias due to self-reported depression symptoms and medical status
  • Observational study design limits the ability to infer causal relationships
  • Findings from a Chinese population may not fully generalize to other countries and populations
  • Did not adjust for potential confounders such as financial situation and cognition
  • Lack of substantial novelty as it verifies previous findings

Cite This Study

Hu et al. (2022) conducted a cohort in Activities of daily living (ADL) disability (n=10,864). Depressive symptoms vs. No depressive symptoms was evaluated on Incident ADL disability (HR 1.54, 95% CI 1.30-1.82). The presence of depressive symptoms was independently associated with a 54% increased risk of incident ADL disability (HR 1.54) compared to those without depressive symptoms.

synapsesocial.com/papers/6aace42cd0cf774bc88583fehttps://doi.org/10.3389/fpsyt.2022.848255
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Bidirectional association between ADL disability and depressive symptoms among older adults: longitudinal evidence from CHARLS2025 · 25 citations
  2. 2Examining the impact of chronic diseases on activities of daily living of middle-aged and older adults aged 45 years and above in China: a nationally representative cohort study2024 · 19 citations
  3. 3Daily Living, Depressive Symptoms, and Cognition in Older Adults With Chronic Diseases2026
  4. 4Depressive symptoms of older adults with chronic diseases: the mediating roles of activities of daily living and economic burden of diseases2024 · 7 citations
  5. 5Bidirectional, longitudinal associations between depressive symptoms and IADL/ADL disability in older adults in China: a national cohort study2024 · 21 citations