Key result
ADL disability linked to ~9% greater risk of depressive symptoms in a bidirectional relationship.
Why the study?
The study was conducted to investigate the bidirectional relationship between Activities of Daily Living disability and depressive symptoms among middle-aged and older adults in China.
Is there a bidirectional relationship between Activities of Daily Living (ADL) disability and depressive symptoms among middle-aged and older adults?
Population
Middle-aged and older adults in China (8994 and 9673 participants in bidirectional analyses)
Comparison
ADL disability and depressive symptoms exposures
Design
Longitudinal cohort study
Follow-up
2015 to 2018
Authors
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Supports monitoring both in older adults; hypothesis-generating and requires trials before guiding care.
Cohort (n=8,994)
Yes
Is there a bidirectional relationship between Activities of Daily Living (ADL) disability and depressive symptoms among middle-aged and older adults?
Hazard Ratio: 1.09 (95% CI 1.058–1.123)
p-value: p=<0.001
There is a significant bidirectional relationship between ADL disability and depressive symptoms in middle-aged and older adults, emphasizing the need for integrated interventions targeting both physical function and mental health.
Yan et al. (2025) conducted a cohort in Depressive symptoms and Activities of Daily Living (ADL) disability (n=8,994). Activities of Daily Living (ADL) disability vs. No ADL disability was evaluated on Risk of developing depressive symptoms (HR 1.090, 95% CI 1.058-1.123, p=<0.001). Activities of Daily Living (ADL) disability significantly increased the risk of depressive symptoms (HR 1.090), and depressive symptoms were reciprocally associated with a higher risk of ADL disability (HR 1.033).
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