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October 19, 2025International Journal of Molecular SciencesOpen Access

Synaptic Plasticity-Enhancing and Cognitive-Improving Effects of Standardized Ethanol Extract of Perilla frutescens var. acuta in a Scopolamine-Induced Mouse Model

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Authors

JLJihye LeeELEunhong LeeHKHyuck Moon Kwon

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Overview

Cohort study shows Perilla frutescens improves cognitive performance in scopolamine-treated mice, indicating therapeutic potential for memory deficits.

Key Points

  • PE significantly enhances long-term potentiation, ameliorating scopolamine-induced cognitive impairment.
  • Treatment with PE at various doses improved memory performance across behavioral tasks in mice.
  • The study used male ICR mice with scopolamine-induced cognitive impairments to assess PE’s effects.
  • Findings suggest that PE may offer therapeutic benefits for memory issues related to cholinergic dysfunction.

Cite This Study

Lee et al. (2025) studied this question.

synapsesocial.com/papers/68f4b10d3d9d770bbc696dd3https://doi.org/10.3390/ijms26209925
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Anti-Neuroinflammation Effect of Standardized Ethanol Extract of Leaves of Perilla frutescens var. acuta on Aβ-Induced Alzheimer’s Disease-like Mouse Model2025
  2. 2Effects of a Natural Polyherbal Extract on Alleviating Scopolamine-Induced Memory Deficits in C57BL/6 Mice via Enhancing Cholinergic Function2025 · 1 citations
  3. 3Protective Effects of a Propolis-<i>Petasites japonicus</i> Mixture on Scopolamine-Induced Memory Impairment in Mice.2026 · 1 citations
  4. 4Enhancement of Memory and Synaptic Plasticity by <i>Celastrus paniculatus</i> Seed Extract: Upregulation of pSer831-GluA1 Trafficking and Arc/PSD-95 Expression in the Hippocampus of Male Rats.2026 · 1 citations
  5. 5Walnut-Derived Peptides Ameliorate Scopolamine-Induced Memory Impairments in a Mouse Model via Activation of Peroxisome Proliferator-Activated Receptor γ-Mediated Excitotoxicity2024 · 11 citations