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May 1, 2026

Protective Effects of a Propolis-Petasites japonicus Mixture on Scopolamine-Induced Memory Impairment in Mice.

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Randomized trial demonstrates protective effects against memory impairment in mice, suggesting therapeutic potential.

This research aims to evaluate the protective effects of a Propolis-Petasites japonicus mixture against memory impairment induced by scopolamine.
Male C57BL/6 mice were pretreated with Propolis-Petasites japonicus mixture prior to scopolamine administration.
Spatial learning and memory were evaluated using the Morris water maze; AChE and ChAT activities were measured to assess cholinergic function.
Western blot analysis was conducted to examine neuroplasticity signaling pathways and neuroinflammatory markers.
PPJM pretreatment significantly reduced escape latency and increased time spent in the target quadrant in the Morris water maze (p<0.01).
Cholinergic function was partially restored, evidenced by reduced AChE activity and increased ChAT activity in the hippocampus (p<0.05).
PPJM increased BDNF-TrkB-AKT-CREB signaling and reduced p-Tau and MAPK activation, along with decreased neuroinflammatory markers NF-κB, COX-2, TNF-α, and IL-6.

Kim et al. (2026) studied this question.

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