Investigating Schisandra chinensis pomace effects on cholinergic dysfunction in neurodegeneration, indicating potential therapeutic benefits.
Key Points
To evaluate the effects of Schisandra chinensis pomace on cognitive impairment caused by cholinergic dysfunction related to neurodegenerative conditions.
Conducted ex vivo electrophysiological and in vivo behavioral studies.
Administered oral Schisandra chinensis pomace to C57BL/6N mice over six weeks.
Evaluated hippocampal long-term potentiation and memory retention using tests like passive avoidance and Morris water maze.
SSP at 0.1 mg/mL significantly restored hippocampal long-term potentiation suppressed by scopolamine.
At 50 mg/kg, SSP prevented body weight loss and improved memory retention.
SSP reduced the p-JNK/JNK ratio, indicating modulation of neurotrophic signaling pathways.