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This is a Meta-Analysis study (also classified as: Systematic Review).

A study on UGT1A1 and ABCG8 gene polymorphism: meta-analysis and bioinformatics approach in the etiology of gallstone disease

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UGT1A1 rs6742078 variant shows a significant association with gallstone disease, indicating a genetic predisposition.
The ABCG8 rs11887534 polymorphism has a stronger association with gallstone disease, with an odds ratio of 2.573.
Meta-analysis pooled data from over 6,492 cases and evaluated the associations using bioinformatics tools for SNP assessment.
Findings highlight the importance of glucuronidation and cholesterol transport pathways in the etiology of gallstone disease.

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Meta-analysis finds significant links between UGT1A1 and ABCG8 polymorphisms and gallstone disease, suggesting genetic influences.

Shireen et al. (2025) studied this question.

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