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October 20, 2025Journal of Pioneering Medical Science

Prevalence of Resistance Genes GyrB, in Particular, Indicates Widespread Resistance to Carbapenem in Acinetobacter baumannii

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Authors

MFMichel FayadFAFatin Ali Al-Chalabi

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Overview

Analysis shows high gyrB prevalence and mutations linked to carbapenem resistance in clinical isolates, suggesting urgent molecular surveillance.

Key Points

  • Among 50 clinical isolates of Acinetobacter baumannii, 86.7% showed resistance to imipenem and meropenem, indicating significant therapeutic challenges.
  • The gyrB gene was present in 92% of isolates, with mutations affecting both fluoroquinolone susceptibility and potential multidrug resistance.
  • A strong correlation was found between gyrB-positive strains and elevated MICs for carbapenems and fluoroquinolones, pointing to severe resistance issues.
  • These findings highlight the critical need for advanced monitoring and novel treatment options to address the growing challenge of resistant Acinetobacter baumannii.

Cite This Study

Fayad et al. (2025) studied this question.

synapsesocial.com/papers/68f5fcd68d54a28a75cf2115https://doi.org/10.47310/jpms2025140924
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Resistance Mechanisms Of Acinetobacter Baumannii In North Indian Clinical Isolates: A Molecular Study Of Β-Lactam, Carbapenem, Cephalosporin, Fluoroquinolone, And Aminoglycoside Genes2025
  2. 2Genotyping and Molecular Analysis of Carbapenem-Resistant <i>Acinetobacter baumannii</i>: Correlations Between Antibiotic Resistance and Virulence Genes2025
  3. 3Genotypic Detection of Carbapenems Resistance Genes in Acinetobacter baumannii Isolated from Urinary Tract Infection Patients2024
  4. 4Genotypic Detection of Carbapenems Resistance Genes in Acinetobacter baumannii Isolated from Urinary Tract Infection Patients2024
  5. 5Molecular Analysis of Gene Collections Associated with Carbapenem-Resistant Acinetobacter baumannii: Systematic review2025