Uji Aktivitas Antibakteri Sediaan Gel Ekstrak Daun Kayu Jawa (Lannea coromandelica) Terhadap Propionibacterium acnes

This study aims to evaluate the antibacterial activity of gel preparations formulated with Java Tree Leaf extract (Lannea coromandelica) against Propionibacterium acnes, as well as to assess the physical stability of the gel. An experimental laboratory design was used, employing the maceration method with 96% ethanol as the solvent. The gel was prepared in three extract concentrations: 3%, 6%, and 9%, and was evaluated for physical properties including organoleptic characteristics, pH, homogeneity, viscosity, spreadability, and adhesiveness. Antibacterial activity was assessed using the disc diffusion method against P. acnes. The results showed that all gel formulations met the required physical quality standards and demonstrated significant antibacterial activity. The inhibition zones for 3%, 6%, and 9% extract concentrations were 10.16 mm, 14.12 mm, and 18.43 mm, respectively, all classified as strong. The negative control exhibited no antibacterial activity, while the positive control produced a 20.12 mm inhibition zone. These findings indicate that Java Tree Leaf extract can be effectively formulated into a gel and has strong antibacterial potential against P. acnes, with higher extract concentrations leading to greater inhibitory effects.