Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
October 20, 2025Synthesis

Photoinduced Pd-Catalyzed Selective 1,4-Dicarbofunctionalization of 1,3-Butadiene with Alkyl or Aryl Bromides and Oxindoles

View Full Paper
Ask AI
Bookmark
Share

Authors

MSMostafa SayedXRXiao‐Yun RuanDWDan-Xing Wu

Discussion

Loading...

Member takes

Overview

This method demonstrates selective 1,4-dicarbofunctionalization in 1,3-butadiene, highlighting the efficiency of photoinduced palladium catalysis.

Key Points

  • The method achieves good yields of up to 93% for 1,4-dicarbofunctionalization of 1,3-butadiene.
  • Utilizing photoexcited Pd(0) species, the reaction accommodates nucleophilic alkyl and electrophilic aryl radicals.
  • The transformation delivers 80 oxindole derivatives with notable regioselectivity of over 20:1.
  • The approach provides efficient access to bioactive oxindole scaffolds under mild reaction conditions.

Cite This Study

Sayed et al. (2025) studied this question.

synapsesocial.com/papers/68f6379bb481a140a36cf85bhttps://doi.org/10.1055/a-2700-2940
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1<b>Visible light-promoted</b> Pd-catalyzed regioselective 1,4-dicarbofunctionalization of 1,3-butadiene with unactivated bromides and malononitriles2025 · 2 citations
  2. 2Catalytic Asymmetric Cascade Dearomatization of Indoles via a Photoinduced Pd‐Catalyzed 1,2‐Bisfunctionalization of Butadienes2024
  3. 3Catalytic Asymmetric Cascade Dearomatization of Indoles via a Photoinduced Pd‐Catalyzed 1,2‐Bisfunctionalization of Butadienes2024 · 44 citations
  4. 41,4‐Aminoarylation of Butadienes via Photoinduced Palladium Catalysis2024 · 53 citations
  5. 51,4‐Aminoarylation of Butadienes via Photoinduced Palladium Catalysis2024 · 4 citations