Molecularly Imprinted Polymers - Coated Eccentric Core Optical Fiber - based SPR Sensor for Glucose Detection

Abstract The detection of glucose is a critical aspect of healthcare and biomedical research, particularly for the management of diabetes mellitus. Among various sensing technologies, Surface Plasmon Resonance (SPR)-based optical fiber sensors have emerged as a promising platform due to their high sensitivity, real-time monitoring capabilities, and miniaturization potential. This article explores the development and application of a Molecularly Imprinted Polymer-coated eccentric core optical fiber SPR sensor for glucose concentration detection. The integration of MIP technology with SPR sensing allows for enhanced specificity and selectivity towards glucose molecules. The design of the eccentric structure of optical fiber contributes to improved light interaction and sensitivity. The amplitude sensitivities are calculated as 1.77 [RIU]-1 for 3% glucose solution, 0.72 [RIU]-1 for 3.5% glucose solution, 0.41 [RIU]-1 for 4% glucose solution, 0.78[RIU]-1 for 5% glucose solution and 0.49[RIU]-1 for 7% glucose solution. The sensor exhibits higher sensitivity to low-concentration glucose solutions than to high-concentration ones. The proposed sensor presents itself as a promising candidate for biochemical sensing of low-concentration glucose solutions with simple geometries.