Intensity-Modulated Molecularly Imprinted Polymer-Coated SPR Fiber Sensor for Detection of Glucose Solution

The detection of glucose is a critical aspect of healthcare and biomedical research, particularly for the management of diabetes mellitus. Among various sensing technologies, surface plasmon resonance (SPR)-based optical fiber sensors have emerged as a promising platform due to their high sensitivity, real-time monitoring capabilities, and miniaturization potential. This paper explores the development and application of a molecularly imprinted polymer (MIP)-coated eccentric core optical fiber SPR sensor for glucose concentration detection. The integration of MIP technology with SPR sensing enables enhanced specificity and selectivity towards glucose molecules, while the eccentric core structure of the optical fiber contributes to improved light–matter interaction and sensitivity. The amplitude sensitivities are calculated as 0.88771 [mmol/mL]−1 for the 3% glucose solution, 0.35161 [mmol/mL]−1 for the 3.5% solution, 0.20425 [mmol/mL]−1 for the 4% glucose solution, 0.89041 [mmol/mL]−1 for the 5% solution, and 1.55825 [mmol/mL]−1 for the 7% solution. The proposed sensor exhibits a simple geometry and presents itself as a promising candidate for glucose solution concentration detection.