Prospective observational study found 5.9% non-adherence to oral anticoagulation therapy after acute pulmonary embolism, indicating need to address risk factors like stroke and diabetes mellitus.
Background Oral anticoagulation (OAC) therapy is essential to avoid venous thromboembolism recurrence, but drug-adherence sometimes might be poor. Aim To describe OAC adherence in patients after acute pulmonary embolism (PE) and to identify risk factors for non-adherence. Methods We prospectively evaluated 324 PE patients (mean age 62.9 ± 14.3, 51.5% male) after 3, 6, 12 and 24 months, resulting in 1620 study visits. Data were analyzed using multivariable logistic models. Results Out of the study population, 19 patients (5.9%) were identified to be non-adherent to OAC therapy. Significant predictors of non-adherence were a history of stroke and diabetes mellitus (DM) (OR = 6.07, 95% CI 1.58-23.36, P = .027 and OR = 3.46, 95% CI 1.15-10.40, P = .009, respectively). Conclusion The adherence rate to OAC is quite high in patients after acute PE, but patients with DM and a history of stroke should be focused on in order to further improve OAC adherence.
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Mayr et al. (2025) studied this question.
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