What type of study is this?

This is a Cohort Study study (also classified as: Quantitative Study, Experimental Study).

October 23, 2025Biology OpenOpen Access

Unraveling enteroendocrine cell lineage dynamics and associated gene regulatory networks during intestinal development

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Observational analysis identified enteroendocrine cells developing from stem cells, suggesting differentiation is independent of diet or microbiota.

Enteroendocrine cells specified during development peak in both human and mouse models, and their absence may lead to malabsorption.
Characterization through single-cell transcriptomics revealed lineage dynamics of enteroendocrine cells in developing intestines.
Approach included mouse embryos and human stem cell-derived organoids to understand enteroendocrine cell differentiation.
Findings indicate that enteroendocrine cell subtype development relies on tissue maturation, not just nutrition or microbiota influence.

Jiménez et al. (2025) studied this question.

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October 23, 2025Biology OpenOpen Access

View Full Paper

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Authors

Observational analysis identified enteroendocrine cells developing from stem cells, suggesting differentiation is independent of diet or microbiota.

Enteroendocrine cells specified during development peak in both human and mouse models, and their absence may lead to malabsorption.
Characterization through single-cell transcriptomics revealed lineage dynamics of enteroendocrine cells in developing intestines.
Approach included mouse embryos and human stem cell-derived organoids to understand enteroendocrine cell differentiation.
Findings indicate that enteroendocrine cell subtype development relies on tissue maturation, not just nutrition or microbiota influence.

Jiménez et al. (2025) studied this question.

View Full Paper

Ask AI

Bookmark