Colchicine and Cardiovascular Disease: Mechanisms, Clinical Evidence, and Therapeutic Perspectives

Colchicine, a long-established anti-inflammatory agent, has recently drawn growing interest due to its possible therapeutic roles in cardiovascular disorders. By modulating inflammatory pathways, colchicine has been shown to enhance clinical outcomes in patients with pericarditis, coronary artery involvement, as well as postoperative atrial fibrillation, and to lower the risk of recurrent cardiovascular events. Nevertheless, its underlying pharmacological mechanisms and sustained benefits still warrant comprehensive evaluation. This review summarizes current understanding of colchicine’s mechanisms, clinical evidence, and prospective applications, offering updated perspectives for its use in cardiovascular medicine.