Key result
Colchicine represents a potential therapy to treat and prevent cardiovascular events such as pericarditis, atrial fibrillation, and ischemic vascular events by targeting neutrophil inflammation.
This review explores the pharmacology, potential efficacy, and safety of colchicine for emerging cardiovascular indications including pericarditis, atrial fibrillation, and ischemic vascular events.
Colchicine may merit targeted investigation for neutrophil-driven events; leaves open routine use pending randomized confirmation.
Colchicine is an ancient drug with anti-inflammatory effects especially on neutrophils. These cells are critically involved in pericardial and atherosclerotic plaques inflammation, thus representing a new potential target for new therapies to treat and especially prevent cardiovascular events such as pericarditis, atrial fibrillation triggered by inflammation and ischemic vascular events. The aim of the present review is to briefly review the essential pharmacology and explore potential efficacy and safety of colchicine for new emerging cardiovascular indications.
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Imazio et al. (2015) conducted a review in Cardiovascular events (pericarditis, atrial fibrillation, ischemic vascular events). Colchicine was evaluated. Colchicine represents a potential therapy to treat and prevent cardiovascular events such as pericarditis, atrial fibrillation, and ischemic vascular events by targeting neutrophil inflammation.
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