Treatment with ornithine aspartate improved sucrose preference in mice with non-alcoholic steatohepatitis, indicating decreased anhedonia.
This study aimed to evaluate the potential antidepressant effect of ornithine aspartate (LOLA) (3 g/kg/day for 3 months) in mice with an alimentary/toxic model of non-alcoholic steatohepatitis (NASH) (n=70). Animals with NASH demonstrated a significantly decreased sucrose preference, which indicated the presence of food anhedonia. Treatment with LOLA provided a significant anti-anhedonic effect.
No takes yet. Share an insight, caveat, or question.
Prikhodko et al. (2025) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: