Assessment reveals neuroprotective and antigenotoxic effects of Prunella grandiflora against etoposide in Drosophila models, suggesting a therapeutic role for this plant.
The search for effective therapies against oncological diseases remains one of the most acute problems in modern healthcare. The side effects of chemotherapy drugs often reduce immunity and lead to multiple complications. In this work, we aimed to evaluate the protective properties of Prunella grandiflora L. against the toxic and genotoxic effects of etoposide using a Drosophila model with mutations in the dFOXO gene. Oregon-R and Foxo25 fly lines were cultured on a medium with the addition of etoposide at a concentration of 0.04 μg/ml and 10% alcoholic extract of P. grandiflora, as well as with the combined introduction of these components. The experiment established no toxic effect of P. grandiflora and its antigenotoxic, geroprotective, and neuroprotective properties in relation to the effects of the antitumor drug etoposide.
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Zhudlovsky et al. (2025) studied this question.
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