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October 23, 2025CancersOpen Access

The Impact of Local Ablative Therapies as Bridging Treatment on Overall Survival Following Liver Transplantation in Patients with HCC

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Authors

LSLaura SchwenkFDFelix DondorfOROliver Rohland

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Overview

Retrospective analysis shows neoadjuvant therapies improve overall survival in liver transplantation for hepatocellular carcinoma, suggesting tailored approaches may be needed.

Key Points

  • Overall survival rates post-liver transplantation were significantly higher for patients who received neoadjuvant therapies.
  • Among 107 patients, 90 received neoadjuvant therapy, yielding 1-, 3-, and 5-year OS rates of 93.5%, 82.2%, and 79.4%, respectively.
  • Retrospective analysis evaluated patients undergoing living donor liver transplantation at Jena University Hospital from 2019 to 2023, examining treatment impacts.
  • Findings suggest that tailored neoadjuvant therapies may optimize outcomes based on tumor burden and transplantation criteria.

Cite This Study

Schwenk et al. (2025) studied this question.

synapsesocial.com/papers/68f9f86eb2c35e10cc4e3d8dhttps://doi.org/10.3390/cancers17203393
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Post-Transplant HCC Recurrence and Survival: Impact of Bridging Therapy and Tumor Biology in 185 Consecutive Liver Transplants2026
  2. 2Locoregional therapy for hepatocellular carcinoma before transplant: Impact on tumor necrosis, tumor recurrence, and long-term survival.2026
  3. 3Liver Transplantation for Hepatocellular Carcinoma beyond the Milan Criteria: A Specific Role for Living Donor Liver Transplantation after Neoadjuvant Therapy2024 · 2 citations
  4. 4Evolving trends and comparative outcomes of bridging transarterial locoregional therapy in liver transplant candidates with hepatocellular carcinoma2025 · 2 citations
  5. 5Bridge Therapy before Liver Transplant for Advanced Hepatocellular Carcinoma2024