October 23, 2025CatalystsOpen Access

Enhancing Electron Transfer in Cytochrome P450 Systems: Insights from CYP119–Putidaredoxin Interface Engineering

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Insights uncover enhanced binding affinity and electron transfer in cytochrome P450 enzymes, suggesting improved biocatalysts design.

Enhanced electron transfer observed in cytochrome P450 systems with mutations to Pdx.
Key mutations N34E and D77R improved binding affinity, achieving up to 20-fold increase.
Assessment through site-directed mutagenesis and structural analysis using docking simulations.
Findings indicate need for balance between binding affinity and electron transfer efficiency for practical applications.

Kakimova et al. (2025) studied this question.

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