This platform demonstrates reproducibility in detecting antibiotics, like trimethoprim, suggesting effective monitoring in water quality.
Surface-enhanced Raman spectroscopy (SERS) is a powerful tool for the rapid, real-time monitoring of trace aquatic pollutants. However, a major challenge persists in the development of SERS substrates capable of simultaneously determining and degrading pollutants. Herein, a highly sensitive Au/TiO2/Au sandwich-structured substrate was fabricated that exhibited excellent SERS performance with an enhancement factor (EF) of 1.05 × 107. Limits of detection (LODs) as low as 1.42 × 10−7 M for ofloxacin (OFL) and 1.26 × 10−9 M for trimethoprim (TMP) were achieved. Notably, the substrate retained stable SERS activity even after five consecutive detect-degrade cycles. By integrating plasmonic enhancement (for SERS detection) with photocatalytic degradation (for pollutant removal), this dual-functional platform demonstrated high reproducibility, with a relative standard deviation (RSD) below 6%, and long-term stability, retaining 60% of its initial SERS intensity after 60 days of storage. The strategy reported herein provides a practical approach for the simultaneous determination and degradation of antibiotics in aqueous matrices.
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Wang et al. (2025) studied this question.
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