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October 23, 2025Signal Transduction and Targeted TherapyOpen Access

Proliferative diabetic retinopathy subtypes defined by immune defense and endothelial mitochondrial dysfunction

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Authors

MMMaximilian McCannBBBasma BaccoucheYLYueru Li

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Overview

Analysis reveals distinct proliferative diabetic retinopathy types characterized by immune and endothelial cell differences, suggesting new therapeutic targets.

Key Points

  • Pathological angiogenesis is a key feature of diabetic retinopathy, leading to potential treatment strategies.
  • Endothelial cells were predominant in some patients, while immune cells and gene expression programs were highlighted in others.
  • Assessment indicated that preclinical testing via the murine oxygen-induced retinopathy model has limitations in understanding human PDR.
  • Anti-VEGF therapy impacts both endothelial and immune cells, offering insights into treatment implications.

Cite This Study

McCann et al. (2025) studied this question.

synapsesocial.com/papers/68fa32a40df2e6cd2f74205ahttps://doi.org/10.1038/s41392-025-02448-9
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