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October 23, 2025Discover OncologyOpen Access

Molecular characterization of macrophage-related prognostic factors in glioblastoma revealed by combined analysis on single-cell and bulk transcriptome data

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Authors

ZWZhihao WeiHLHongchao LiuYYYajun Yang

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Overview

Analysis identified a prognostic model involving immune checkpoints in glioblastoma, suggesting new therapeutic targets.

Key Points

  • The study reveals significant correlations between immune checkpoints and prognosis in glioblastoma.
  • Immune checkpoints showed significant associations with the core genes in glioblastoma patients.
  • Assessment using single-cell transcriptomic analysis highlighted critical macrophage-related modules.
  • Findings suggest Ribociclib's potential impact on treatment strategies for glioblastoma patients.

Cite This Study

Wei et al. (2025) studied this question.

synapsesocial.com/papers/68fa32a40df2e6cd2f7422e7https://doi.org/10.1007/s12672-025-03816-1
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Identification of a prognostic signature consisting of three macrophage-related genes for glioblastoma based on bulk and single-cell transcriptomes analyses.2025
  2. 2Potential Prognostic Markers for Glioblastoma Associated with the Glioma Immune Microenvironment2025 · 2 citations
  3. 3Integrative single-cell and bulk transcriptome analyses identify a distinct pro-tumor macrophage signature that has a major prognostic impact on glioblastomas2024 · 3 citations
  4. 4Integrative Single-Cell and Bulk Transcriptome Analysis Reveals Molecular Mechanisms, Prognostic Signatures, and Therapeutic Response in Glioma2026
  5. 5TMIC-69. Macrophage-associated genes as prognostic biomarkers in mesenchymal glioblastoma2025