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November 1, 2025Neuro-OncologyOpen Access

TMIC-69. Macrophage-associated genes as prognostic biomarkers in mesenchymal glioblastoma

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Authors

GLGeraldine LeeJLJessica LaiAMAngela Major

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Overview

Study demonstrates prognostic biomarkers for glioblastoma, highlighting the role of macrophages in immunosuppression.

Key Points

  • This research aims to determine if macrophage-associated gene signatures predict outcomes in glioblastoma patients.
  • RNA-seq data from 288 GBM patients analyzed
  • Macrophage-related gene sets evaluated using Gene Set Enrichment Analysis
  • Survival analysis conducted using Kaplan-Meier method and Cox regression
  • Distinct macrophage profiles identified among glioblastoma subtypes
  • High RETN, LSP1, and CTSB expression correlates with poorer survival
  • High-expression groups had shorter median survival and lower overall survival rates

Cite This Study

Lee et al. (2025) studied this question.

synapsesocial.com/papers/6925436cc0ce034ddc358675https://doi.org/10.1093/neuonc/noaf201.1824
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  1. 1Integrative single-cell and bulk transcriptome analyses identify a distinct pro-tumor macrophage signature that has a major prognostic impact on glioblastomas2024 · 3 citations
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  4. 4Potential Prognostic Markers for Glioblastoma Associated with the Glioma Immune Microenvironment2025 · 2 citations
  5. 5Molecular Determinants of Macrophage Polarization in Glioblastoma and Implications for Tumor Progression2026