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October 27, 2025

The Ability of Activity and Cognition in Old Mice to Predict Age of Death.

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Authors

SLSreemathi LoganKKKavitha KurupMCMichael Chan

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Overview

Analysis shows C57BL/6 mouse activity and healthspan predict lifespan, indicating mortality correlates with voluntary activity.

Key Points

  • Voluntary running activity positively correlates with lifespan in C57BL/6 mice, suggesting activity impacts longevity.
  • A multiple regression model identified movement and cognitive factors that explain 55% of lifespan variance in female mice and 21% in males.
  • Cognitive measures during a working memory task did not predict lifespan, despite links to daytime activity and sleep quality.
  • These findings underscore the significance of physical activity and cognitive functioning in aging and mortality.

Cite This Study

Logan et al. (2025) studied this question.

synapsesocial.com/papers/68ff87e2c8c50a61f2bdcdcfhttps://doi.org/10.14336/ad.2025.1056
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