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November 13, 2025Aging CellOpen Access

Longitudinal Testing of Exploratory Behaviour in Mice Reveals Stable Cognitive Traits Across the Adult Lifespan

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Authors

RAR AbuhamdahGMG. MooreDDD Djama

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Overview

Longitudinal testing demonstrates stable cognitive performance in C57BL/6J mice, suggesting early traits affect ageing outcomes.

Key Points

  • To evaluate if cognitive ability is a stable trait throughout the adult lifespan of mice.
  • Conducted longitudinal cognitive testing in female C57BL/6J mice aged 4 to 18 months.
  • Tracked individual performance in various cognitive tasks over time.
  • Investigated age-related changes in prefrontal cortex neurons through single-cell recording.
  • Cognitive performance at 4 months predicted performance at 18 months.
  • No variability link was found to macroscopic brain structure differences.
  • Early exploration strategies in a nine-arm radial maze were maintained over the lifespan.

Cite This Study

Abuhamdah et al. (2025) studied this question.

synapsesocial.com/papers/692523c6c0ce034ddc354e7chttps://doi.org/10.1111/acel.70287
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