October 15, 2020International Journal of Molecular SciencesOpen Access

Role of Cadherins in Cancer—A Review

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Destabilization of the cadherin-catenin complex impairs tissue homeostasis and accelerates tumor progression, promoting invasion across neoplastic tissues.
Review outlines how downregulation of e-cadherin and dysregulated beta-catenin signaling drive epithelial mesenchymal transition during oncogenesis.
Targeting cadherin signaling and downstream rho gtpases highlights promising therapeutic strategies, though human and veterinary clinical utility requires validation.

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Implication

Review discusses cadherin dysfunction and signaling pathway interactions in human and animal cancers, suggesting that cadherin-targeting therapies may suppress progression.

Cite This Study

Kaszak et al. (2020) studied this question.

synapsesocial.com/papers/69026a720c0b46d174da00b3 https://doi.org/10.3390/ijms21207624

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Implication

Review discusses cadherin dysfunction and signaling pathway interactions in human and animal cancers, suggesting that cadherin-targeting therapies may suppress progression.

Role of Cadherins in Cancer—A Review

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Discussion

Implication

Cite This Study

Role of Cadherins in Cancer—A Review

Key Points

Discussion

Implication

Cite This Study

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