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November 3, 2025Open Access

Modeling the role of ATP metabolism in articular cartilage and osteoarthritis

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Authors

DMDhruba Jyoti MechMRMohd Suhail Rizvi

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Overview

Mathematical modeling demonstrates metabolic dysfunction in osteoarthritis, highlighting chondrocyte ATP metabolism and systemic interventions.

Key Points

  • Chronic hypoxia leads to reduced ATP levels and progressive ECM loss in osteoarthritis.
  • Physiological simulations revealed the role of metabolic regulators under stochastic fluctuations.
  • Modeling revealed that mechanical loading enhances metabolic flexibility for chondrocytes.
  • Therapeutic interventions targeting metabolic dysfunction effectively reverse glycolytic shifts.

Cite This Study

Mech et al. (2025) studied this question.

synapsesocial.com/papers/6907f1ac0328c9fb7920b58dhttps://doi.org/10.1101/2025.07.17.665362
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Also Consider

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  1. 1Modeling and simulation of the effects of cyclic loading on articular cartilage lesion formation2014 · 14 citations
  2. 2Transmission of Rapidly Applied Loads Through Articular Cartilage Part 1: Uncracked Cartilage1996 · 34 citations
  3. 3Adaptation of chondrocytes to low oxygen tension: Relationship between hypoxia and cellular metabolism1996 · 226 citations
  4. 4Energy metabolism in health and diseases2025 · 345 citations
  5. 5Modeling the effect of blunt impact on mitochondrial function in cartilage: implications for development of osteoarthritis2017 · 11 citations