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November 4, 2025Current Signal Transduction Therapy

Exploring Immune-genomic and Biomarker Insights in Psoriasis: Pathology of Disease and Treatment Advances

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Authors

KNK. S. NegiIndian Institute of Technology KanpurPBPriyanka BansalJaypee Institute of Information TechnologyBPBhavani PentelaJaypee Institute of Information Technology

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Implication

This review explores the role of genetic factors and inflammatory pathways in psoriasis, implying targeted therapies may improve treatment outcomes.

Key Points

  • Psoriasis is significantly impacted by genetic factors and environmental influences, complicating its management.
  • The IL-23/IL-17 axis and Th17 cells are crucial in psoriasis pathogenesis and targeted therapies.
  • Targeted treatments include biologics against TNF-α, IL-17, and IL-23, alongside small-molecule inhibitors like PDE-4.
  • Ongoing research is essential to personalize treatment strategies and tackle associated health issues.

Cite This Study

Negi et al. (2025) studied this question.

synapsesocial.com/papers/690945348f2297dc13532fcehttps://doi.org/10.2174/0115743624407001251017054423
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