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November 9, 2025Clinical and Experimental Pharmacology and PhysiologyOpen Access

Long‐Term Anticoagulation and Outcomes of Head and Neck Cancer: Analysis of the US Nationwide Inpatient Sample

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Authors

CWChenyan WuHLHang LingYZYun‐Cong Zheng

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Overview

Analysis shows long-term anticoagulation reduces in-hospital mortality and severe events in HNC, implying better patient outcomes.

Key Points

  • Long-term anticoagulation significantly decreases in-hospital mortality and life-threatening events in head and neck cancer.
  • Patients on long-term systemic anticoagulation had 64% lower odds of in-hospital mortality and 20% lower odds of an acute myocardial infarction.
  • Analysis of the US Nationwide Inpatient Sample data from 2005 to 2018 across over 20,000 patients was performed using multivariable regression techniques.
  • Elevated bleeding risk was noted; however, it did not significantly increase the risk of intracerebral haemorrhage.

Cite This Study

Wu et al. (2025) studied this question.

synapsesocial.com/papers/690fdcdaf60c54d04ea37e88https://doi.org/10.1111/1440-1681.70087
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Prospective Study of Venous Thromboembolism in Patients With Head and Neck Cancer After Surgery2013 · 87 citations
  2. 2Intracranial hemorrhage with direct oral anticoagulants in patients with brain metastases2020 · 50 citations
  3. 3Safety of Direct Oral Anticoagulants in Central Nervous System Malignancies2021 · 40 citations
  4. 4Update on Guidelines for the Management of Cancer-Associated Thrombosis2020 · 127 citations
  5. 5Incidence of venous thromboembolism following head and neck surgery2023 · 11 citations