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November 22, 2025Nature CommunicationsOpen Access

Assembly of the infant gut microbiome and resistome are linked to bacterial strains in mother’s milk

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Authors

PFPamela FerrettiMAMattea AllertKJKelsey E. Johnson

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Overview

Research demonstrates gut microbiome stability in infants is linked to bacterial strains in human milk, suggesting implications for infant health.

Key Points

  • This research investigates how the maternal milk microbiome influences the development of the infant gut microbiome.
  • Analyzed 507 metagenomic samples from 195 mother-infant pairs
  • Quantified similarity between maternal milk and infant gut microbiomes
  • Assessed microbial overlap and species stability
  • Examined strain sharing and antimicrobial resistance gene carriage
  • Infant gut microbiomes showed greater stability when dominated by Bifidobacterium longum
  • Identified strain sharing between milk and infant gut, including commensal and pathobiont strains
  • Noted enrichment in biosynthetic pathways in infants at one month
  • Observed significant overlap in antimicrobial resistance genes within pairs

Cite This Study

Ferretti et al. (2025) studied this question.

synapsesocial.com/papers/6924e3ddc0ce034ddc34e882https://doi.org/10.1038/s41467-025-66497-y
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Also Consider

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  1. 1Longitudinal Profiling of the Human Milk Microbiome from Birth to 12 Months Reveals Overall Stability and Selective Taxa-Level Variation2025 · 4 citations
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  3. 3Advances in lactation: exploring the role of human breast milk microbiota in neonatal gut maturation2026
  4. 4Post Natal Microbial and Metabolite Transmission: The Path from Mother to Infant2024 · 14 citations
  5. 5Metagenomic assessment of the bacterial breastfeeding microbiome in mature milk across lactation2024 · 1 citations