What question did this study set out to answer?

To investigate a nanodrug that synergizes ferroptosis with radiotherapy to enhance immunotherapy in cold tumors.

November 21, 2025NANO

Dual-Regulated Nanodrug Potentiates Immunotherapy by Synergizing Ferroptosis with Radiotherapy to Reverse the Immunosuppressive Tumor Microenvironment

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Dual-regulated nanodrug improves immunogenic cell death and T-cell infiltration in cold tumors, suggesting a new treatment strategy.

To investigate a nanodrug that synergizes ferroptosis with radiotherapy to enhance immunotherapy in cold tumors.
Developed an iron-based metal-organic framework loaded with disulfiram.
Examined effects of the nanodrug on ferroptosis induction and immunogenic cell death.
Conducted in vivo studies using a 4T1 breast carcinoma model.
Significant tumor suppression observed in the 4T1 model.
Increased CD8+ T cell infiltration and dendritic cell maturation recorded.
Induction of abscopal effects which point to a systemic anti-tumor immune response.

Zhang et al. (2025) studied this question.

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November 21, 2025NANO

View Full Paper

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Authors

Dual-regulated nanodrug improves immunogenic cell death and T-cell infiltration in cold tumors, suggesting a new treatment strategy.

To investigate a nanodrug that synergizes ferroptosis with radiotherapy to enhance immunotherapy in cold tumors.
Developed an iron-based metal-organic framework loaded with disulfiram.
Examined effects of the nanodrug on ferroptosis induction and immunogenic cell death.
Conducted in vivo studies using a 4T1 breast carcinoma model.
Significant tumor suppression observed in the 4T1 model.
Increased CD8+ T cell infiltration and dendritic cell maturation recorded.
Induction of abscopal effects which point to a systemic anti-tumor immune response.

Zhang et al. (2025) studied this question.

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