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November 21, 2025Frontiers in NutritionOpen Access

Effects of intermittent fasting on brain health via the gut–brain axis

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Authors

ZZZiqian ZhaoWGWenting GengYGYan Gao

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Overview

Review reveals intermittent fasting improves gut microbiota and reduces neuroinflammation in neurodegenerative diseases, suggesting new interventions.

Key Points

  • This review aims to synthesize evidence on how intermittent fasting affects brain health through the gut–brain axis.
  • Reviewed preclinical and clinical studies on intermittent fasting and brain health.
  • Analyzed effects on gut microbiota, neuroinflammation, and cognitive functions.
  • Identified the role of metabolic pathways and microbiota-derived metabolites.
  • Intermittent fasting improves gut microbiota composition and reduces neuroinflammation.
  • Significant correlations found between fasting and decreased β-amyloid burden in Alzheimer's models.
  • Intermittent fasting enhances cognitive performance in Parkinson's disease patients.

Cite This Study

Zhao et al. (2025) studied this question.

synapsesocial.com/papers/6924e3ecc0ce034ddc34ed6bhttps://doi.org/10.3389/fnut.2025.1696733
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