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November 21, 2025Journal of Global HealthOpen Access

Utilising bioinformatics and molecular docking technology to explore the underlying mechanisms of intervertebral disc degeneration with potential therapeutic drugs and formulas

Tian Yu-kui Cui Xiao-feng Bai Xue Guo Lei Wang Cheng Liu Jun-chang

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Key Points

To investigate the mechanisms of intervertebral disc degeneration and identify potential therapeutic interventions.
Utilised bioinformatics and molecular docking techniques to analyze targets.
Developed a predictive nomogram based on identified molecular targets.
Explored TCM herbal formulae for therapeutic applications in treatment.
Identified CYP1B1 as a significant target for intervertebral disc degeneration.
Provided insights into clinical treatment strategies for intervertebral disc degeneration.

Implication

Analysis identifies CYP1B1 as a key target in intervertebral disc degeneration, suggesting therapeutic drugs for clinical treatment.

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Cite This Study

Yu-kui et al. (2025) studied this question.

synapsesocial.com/papers/6924e3f2c0ce034ddc34f07c https://doi.org/10.7189/jogh.15.04298

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