Structural connectivity predicts the amelioration of postoperative rapid eye movement sleep behavior disorder in Parkinson's disease patients who underwent subthalamic nucleus–deep brain stimulation

Yu-Si Chen; Wei Jiang; Mengying Wang; Kai Shu; Hui-cong Kang

doi:10.1016/j.compbiomed.2025.111289

November 20, 2025Computers in Biology and MedicineOpen Access

Structural connectivity predicts the amelioration of postoperative rapid eye movement sleep behavior disorder in Parkinson's disease patients who underwent subthalamic nucleus–deep brain stimulation

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Key Points

To explore how structural connectivity influences recovery from rapid eye movement sleep behavior disorder in Parkinson's disease patients post-surgery.
Evaluated the effectiveness of STN deep brain stimulation (DBS) in patients with Parkinson's disease and RBD.
Conducted neuroimaging to assess structural connectivity related to electrode placement.
Analyzed postoperative improvements in RBD symptoms based on connectivity metrics.
Subthalamic nucleus DBS significantly improved RBD symptoms in Parkinson's patients.
The effectiveness of the surgery was correlated with the structural connections of electrode placements to specific brain fiber tracts.

Implication

Neuroimaging indicates fibers associated with subthalamic nucleus deep brain stimulation improves behavioral disorders in Parkinson's patients.

Abstract

The effectiveness of STN-DBS for PD-RBD is significantly related to the VTA of electrodes. An appreciable effect may be achieved from VTA circumscribing the STN associative subnucleus, anterior thalamic radiation-9p, DRTT-SFL, and superior thalamic radiation-8BL fibers.

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Cite This Study

Chen et al. (2025) studied this question.

synapsesocial.com/papers/6924e405c0ce034ddc34f8e7 https://doi.org/10.1016/j.compbiomed.2025.111289

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Structural connectivity predicts the amelioration of postoperative rapid eye movement sleep behavior disorder in Parkinson's disease patients who underwent subthalamic nucleus–deep brain stimulation

Key Points

Implication

Abstract

Discussion

Cite This Study

Structural connectivity predicts the amelioration of postoperative rapid eye movement sleep behavior disorder in Parkinson's disease patients who underwent subthalamic nucleus–deep brain stimulation

Key Points

Implication

Abstract

Discussion

Cite This Study

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