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November 20, 2025Stem Cell Research & TherapyOpen Access

Unveiling the role of gastric cancer-associated mesenchymal stem cells and neutrophil extracellular traps through multi-omics analysis

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Authors

ZLZhengrui LiPLPeng LuoZZZhaokai Zhou

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Overview

Analysis reveals tumor progression ties to neutrophil extracellular traps in gastric cancer, indicating immune modulation.

Key Points

  • Tumor progression is strongly linked to neutrophil extracellular traps and GC-MSCs in gastric cancer.
  • Single-cell RNA sequencing identified distinct cell types in an aggressive tumor microenvironment.
  • Mendelian randomization confirmed EIF1 and RPS12 as key genes associated with immune cell infiltration.
  • Implications suggest potential targets for precision medicine in gastric cancer treatment.

Cite This Study

Li et al. (2025) studied this question.

synapsesocial.com/papers/6924f074c0ce034ddc34fc54https://doi.org/10.1186/s13287-025-04768-7
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Integrating Single-Cell Transcriptomic Data of Metastatic Gastric Cancer to Construct a Tumor-Associated Neutrophil Signature and Clinical Validation in MSS/pMMR Patients2025
  2. 2Comprehensive analysis of the tumor immune microenvironment in gastric cancer and peritoneal metastasis based on single-cell RNA sequencing analysis2025
  3. 3Macropinocytosis of neutrophil extracellular trap by gastric cancer cells promotes immune escape and peritoneal metastasis2026
  4. 4Focus on M2-TAMs and gastric cancer: a Mendelian randomization and bioinformatics analysis.2026
  5. 5The tumor microenvironment shapes gastric cancer progression by coordinating immune suppression and metabolic reprogramming2026 · 11 citations