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November 20, 2025Cell RegenerationOpen Access

The role of METTL3 in transposable elements regulation and 2C-like program induction in mouse embryonic stem cell

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Authors

XCXiuyu ChenBCBingqiu ChenYZYingying Zhao

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Overview

Research reveals METTL3's role in gene expression and transposable elements in mouse embryonic stem cells, indicating developmental implications.

Key Points

  • This research aims to examine the role of METTL3 in regulating gene expression and transposable elements in mouse embryonic stem cells.
  • Knockout of Mettl3 in mouse embryonic stem cells (mESCs)
  • Analysis of transposable elements and gene expression
  • Embryo chimera experiments using a METTL3 degradation system (dTAG)
  • Mettl3 knockout leads to upregulation of transposable elements and 2C-like genes
  • METTL3-deficient mESCs contribute to trophectoderm lineages at the blastocyst stage
  • Findings suggest a link between m6A loss and a 2C-like state with extended potency

Cite This Study

Chen et al. (2025) studied this question.

synapsesocial.com/papers/6924f074c0ce034ddc34fc5fhttps://doi.org/10.1186/s13619-025-00262-w
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Essential role of METTL3 in mitochondrial function and epigenetic regulation during preimplantation development in mice2026
  2. 2METTL3 suppresses cardiac differentiation via the PRC2/SMARCA2 Axis2026
  3. 3METTL3 Uncouples Chromatin Accessibility from Transcription during Retinal Development2025
  4. 4METTL3 uncouples chromatin accessibility from transcription during retinal development2025 · 1 citations
  5. 5METTL3 and METTL14 determine human neural fate specifications2025 · 2 citations