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November 20, 2025Advanced ScienceOpen Access

Computational Design and Glycoengineering of Interferon‐Lambda for Nasal Prophylaxis Against Respiratory Viruses

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Authors

JYJeong-Won YunSYSeung-Ju YangJKJae‐Hyuk Kwon

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Implication

Engineering enhances hIFN‐λ3’s thermostability and antiviral action in nasal applications for influenza A virus, suggesting a novel intervention approach.

Key Points

  • The aim is to improve human IFN‐λ3 (hIFN‐λ3) for effective nasal prophylaxis against respiratory viruses.
  • Used artificial intelligence for backbone remodeling
  • Implemented glycoengineering for enhanced solubility
  • Assessed mucosal penetration and antiviral efficacy of the engineered variant
  • Evaluated thermostability and protease resistance of hIFN‐λ3‐DE1
  • Conducted in vivo studies on mucosal administration of G‐hIFN‐λ3‐DE1
  • Engineered variant hIFN‐λ3‐DE1 demonstrates enhanced thermostability exceeding 90 °C
  • Effective inhibition of influenza A virus observed upon intranasal administration
  • Glycoengineering significantly improves production yield and diffusion through synthetic nasal mucus
  • Maintained antiviral activity without systemic inflammation

Cite This Study

Yun et al. (2025) studied this question.

synapsesocial.com/papers/6924f07ac0ce034ddc34ff69https://doi.org/10.1002/advs.202506764
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