Perspectives on Orthology During the Quest for Orthologs

Natasha Glover; David A. Liberles

doi:10.1007/s00239-025-10290-4

November 20, 2025Journal of Molecular EvolutionOpen Access

Perspectives on Orthology During the Quest for Orthologs

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Key Points

Challenges in detecting orthologous genes impact accurate protein function annotation, and ongoing research seeks solutions.
The special issue presents eleven articles focused on orthology and its role in bioinformatics, showcasing diverse perspectives.
Current findings offer insights into the complexities of characterizing orthologs across various species, emphasizing gene relationships.
Community efforts aim to refine methods in orthology detection, enhancing understanding of gene functions and evolutionary biology.

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Implication

This special issue discusses challenges in ortholog detection and protein function annotation in orthologous genes, highlighting community contributions.

Abstract

This special issue from the Quest for Orthologs community highlights ongoing challenges in detecting and characterizing orthologous genes in the annotation of protein functions. Eleven articles are presented describing ongoing research in this area.

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Glover et al. (2025) studied this question.

synapsesocial.com/papers/6924f07fc0ce034ddc350035 https://doi.org/10.1007/s00239-025-10290-4

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Perspectives on Orthology During the Quest for Orthologs

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Perspectives on Orthology During the Quest for Orthologs

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