Large study demonstrates favorable outcomes with proton beam therapy after chemotherapy in locally advanced pancreatic cancer, suggesting a dose-response relationship.
This largest to-date study on PBT for LAPC suggests that hypofractionated SIB-PBT could be a safe and effective local treatment for LAPC. Favorable outcomes were observed with PBT after stable disease following induction chemotherapy, and a potential dose-response relationship was suggested. However, further prospective studies are required to validate our findings.
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Kim et al. (2025) studied this question.
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