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November 20, 2025Organic Chemistry Frontiers

Asymmetric [3+2]/[4+2] Annulations for the Synthesis of ε-Sultams Promoted by Bifunctional Base Catalysts

Chengli Mou Siyi Chen Jun Huang Xin Liu LIEJIN ZHOU Shoulei Wang

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Key Points

Annulations enable the synthesis of chiral ε-sultams through distinct pathways, promoting chemical diversity.
Key metrics include two significant annulation pathways: [3+2] cycloaddition and [4+2] mechanisms involved.
Bifunctional hydrogen-bonding organocatalysis leads the approach to synthesis of these compounds in the study.
These findings highlight potential in advancing asymmetric synthesis techniques via innovative catalytic strategies.

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Implication

Bifunctional catalysts promote synthesis of chiral ε-sultams via [3+2] and [4+2] annulations, suggesting new pathways for organocatalysis.

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Cite This Study

Mou et al. (2025) studied this question.

synapsesocial.com/papers/6924f07fc0ce034ddc350208 https://doi.org/10.1039/d5qo01474c

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