What question did this study set out to answer?

Develop a dynamic kinetic asymmetric [3 + 2] annulation reaction coupling aminocyclopropanes with aldehydes and enol ethers.

April 14, 2014Journal of the American Chemical SocietyOpen Access

Dynamic Kinetic Asymmetric [3 + 2] Annulation Reactions of Aminocyclopropanes

View Full Paper

Ask AI

Bookmark

Develop a dynamic kinetic asymmetric [3 + 2] annulation reaction coupling aminocyclopropanes with aldehydes and enol ethers.
Utilized a copper catalytic system combined with a commercially available chiral bisoxazoline ligand.
Conducted [3 + 2] annulations between aminocyclopropanes and either enol ethers or aldehydes under identical reaction conditions.
Yielded cyclopentyl- and tetrahydrofurylamines in 69% to 99% chemical yields across tested substrates.
Delivered high enantioselectivity, achieving enantiomeric ratios of up to 98:2.

Discussion

No takes yet. Share an insight, caveat, or question.

Implication

Experimental study demonstrates dynamic kinetic asymmetric annulation of aminocyclopropanes, highlighting a versatile route to enantio-enriched bioactive nitrogen building blocks.

Cite This Study

Nanteuil et al. (2014) studied this question.

synapsesocial.com/papers/6a9ca23bc42eb00825f7bbec https://doi.org/10.1021/ja5024578

View Full Paper

Ask AI

Bookmark

Implication

Experimental study demonstrates dynamic kinetic asymmetric annulation of aminocyclopropanes, highlighting a versatile route to enantio-enriched bioactive nitrogen building blocks.

Dynamic Kinetic Asymmetric [3 + 2] Annulation Reactions of Aminocyclopropanes

Key Points

Discussion

Implication

Cite This Study

Dynamic Kinetic Asymmetric [3 + 2] Annulation Reactions of Aminocyclopropanes

Key Points

Discussion

Implication

Cite This Study

Also Consider

Also Consider