What question did this study set out to answer?

This research examines immune cell composition across different tissues in systemic sclerosis patients.

November 20, 2025JDDG Journal der Deutschen Dermatologischen GesellschaftOpen Access

Immune cells composition in the skin and subcutaneous adipose tissue of patients with systemic sclerosis

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Authors

MGMarija Geroldinger-Simić AGAna E. Aguilar GonzálezUniversitätszahnklinik Wien GEGerald Exler

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Implication

Comprehensive analysis reveals distinct immune profiles in skin and subcutaneous adipose tissue, suggesting systemic inflammation in systemic sclerosis.

Key Points

This research examines immune cell composition across different tissues in systemic sclerosis patients.
Used spectral flow cytometry to profile immune cell subsets
Analyzed cells from blood, skin, and subcutaneous adipose tissue
Evaluated associations with clinical features of systemic sclerosis
Mild skin fibrosis correlated with increased cDC1, moDC, and ThGM-CSF cells in the skin
Subcutaneous adipose tissue showed an influx of Th22 cells and reduced NK cells
Lung fibrosis in patients associated with decreased NK cells and increased CD8 + T cells

Cite This Study

Geroldinger-Simić et al. (2025) studied this question.

synapsesocial.com/papers/6924f091c0ce034ddc3507d7 https://doi.org/10.1111/ddg.15864

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Implication

Comprehensive analysis reveals distinct immune profiles in skin and subcutaneous adipose tissue, suggesting systemic inflammation in systemic sclerosis.

Immune cells composition in the skin and subcutaneous adipose tissue of patients with systemic sclerosis

Discussion

Member takes

Implication

Key Points

Cite This Study

Immune cells composition in the skin and subcutaneous adipose tissue of patients with systemic sclerosis

Discussion

Member takes

Implication

Key Points

Cite This Study

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