What does this research mean for the field?

Granulocytic myeloid-derived suppressor cells (G-MDSCs) interact with type 2 innate lymphoid cells (ILC2s) to drive tissue fibrosis in systemic sclerosis. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.ESTABLISHES_NEW_DIRECTION.

What question did this study set out to answer?

To determine the role of myeloid-derived suppressor cells in systemic sclerosis-associated fibrosis and clarify their crosstalk with other immune cell populations.

September 8, 2026Arthritis & Rheumatology

The synergistic impact of granulocytic myeloid‐derived suppressor cells and innate lymphoid cells in systemic sclerosis

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Authors

SWStefanie WeberFriedrich-Alexander-Universität Erlangen-Nürnberg MAMario R. AngeliFriedrich-Alexander-Universität Erlangen-Nürnberg HMHashem MohammadianFriedrich-Alexander-Universität Erlangen-Nürnberg

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Implication

Translational study reveals that myeloid-derived suppressor cells interact with innate lymphoid cells to drive fibrosis in systemic sclerosis, highlighting a novel therapeutic target.

Key Points

To determine the role of myeloid-derived suppressor cells in systemic sclerosis-associated fibrosis and clarify their crosstalk with other immune cell populations.
Analyzed peripheral blood (SSc: N=37, healthy: N=27) using flow cytometry and skin biopsies (SSc: N=9, healthy: N=5) using fluorescence microscopy.
Employed bleomycin-induced mouse models of fibrosis with pharmacological inhibition of Bruton's tyrosine kinase using ibrutinib to disrupt granulocytic myeloid-derived suppressor cell activity.
Integrated single-cell RNA sequencing (skin: 19 SSc, 20 healthy; lung: 7 SSc, 15 healthy) and spatial transcriptomics (skin: 12 SSc, 7 healthy) with bulk RNA sequencing and functional assays.
Granulocytic myeloid-derived suppressor cells were significantly enriched in both the circulation and skin of systemic sclerosis patients, positively correlating with disease severity.
Transcriptomic and functional analyses demonstrated that granulocytic myeloid-derived suppressor cells interact with type 2 innate lymphoid cells to drive a pro-fibrotic environment via IL-13-mediated TGFβ, Arginase1, and CCL24.
Functional assays confirmed that granulocytic myeloid-derived suppressor cells directly stimulate Tgfb1 expression in type 2 innate lymphoid cells to promote tissue fibrosis.

Cite This Study

Weber et al. (2026) studied this question.

synapsesocial.com/papers/6a9fd83b58e84d0ff5b47ab8 https://doi.org/10.1002/art.70325

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Implication

Translational study reveals that myeloid-derived suppressor cells interact with innate lymphoid cells to drive fibrosis in systemic sclerosis, highlighting a novel therapeutic target.

The synergistic impact of granulocytic myeloid‐derived suppressor cells and innate lymphoid cells in systemic sclerosis

Discussion

Member takes

Implication

Key Points

Cite This Study

The synergistic impact of granulocytic myeloid‐derived suppressor cells and innate lymphoid cells in systemic sclerosis

Discussion

Member takes

Implication

Key Points

Cite This Study

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