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November 19, 2025Veterinary PathologyOpen Access

Characterization of host immune cell infiltrate in human CAR T cell-mediated xenogeneic graft versus host disease in NSG mice

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Authors

EWElinor WillisEBEsha BanerjeeJVJillian Verrelle

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Overview

Analysis reveals graft versus host disease in NSG mice treated with CAR T cells targeting tumor-specific antigen, suggesting macrophage polarization implications.

Key Points

  • This study aims to characterize the immune cell infiltrate involved in CAR T cell-mediated xenogeneic graft versus host disease.
  • Analyzed GvHD lesions in NSG mice
  • Compared mice treated with CAR T cells to control mice receiving nontransduced T cells
  • Performed immunohistochemical characterization of GvHD lesions
  • Investigated macrophage polarization in relation to GvHD severity.
  • Mice treated with CAR T cells exhibited more severe GvHD lesions compared to control mice.
  • Tumor burden negatively correlated with GvHD lesion severity.
  • GvHD lesions comprised approximately 45% murine immune cell infiltrate.
  • Macrophages displayed an M2-like polarization phenotype.

Cite This Study

Willis et al. (2025) studied this question.

synapsesocial.com/papers/6924f091c0ce034ddc350a8bhttps://doi.org/10.1177/03009858251391388
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Chronic xenogeneic GVHD after CAR T cell therapy limits long-term safety assessment of CAR effects using NSG mouse model2026
  2. 2In Vivo clonal dynamics of alloreactive CAR T cells reveal mechanisms limiting gvhd risk following allogeneic CAR T cell therapy2025
  3. 3Sclerotic chronic cutaneous graft-versus-host-disease following pseudoallogeneic chimeric antigen receptor T-cell therapy2024
  4. 4Exploring the heterogeneity of primary T cell activity and the implication for preclinical models of CAR T cell therapy 21232025
  5. 5T-cell development and activation in humanized mice lacking mouse major histocompatibility complexes2024