What question did this study set out to answer?

This research examines the long-term effects of CAR T cell therapy in xenogeneic mouse models, focusing on xenogeneic graft-versus-host disease (xenoGVHD).

August 9, 2026Blood AdvancesOpen Access

Chronic xenogeneic GVHD after CAR T cell therapy limits long-term safety assessment of CAR effects using NSG mouse model

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Authors

WFWahed A. Firoz MSMichael K. Sheng PRPedro Ruivo

Discussion

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Overview

Randomized trial demonstrates chronic xenogeneic GVHD impacts CAR T efficacy assessment in NSG mouse models, indicating a need for caution in interpretation.

Key Points

This research examines the long-term effects of CAR T cell therapy in xenogeneic mouse models, focusing on xenogeneic graft-versus-host disease (xenoGVHD).
Altered donor T cells to memory phenotypes for CAR T generation to assess xenoGVHD effects.
Utilized MHCI/II double-knockout NSG mice to confirm the xenoGVHD pathology was mediated by human TCR murine MHC interactions.
Monitored CAR T cell populations and xenoGVHD outcomes over extended post-transfer periods.
A significant delay in lethal xenoGVHD occurrence was observed, with up to 200 days post-transfer for some donor T cells.
Chronic xenoGVHD was characterized by scleroderma and multi-organ pathology occurring without the presence of B cells.
Emergence of CAR-negative T cell populations during xenoGVHD responses was noted, indicating alterations in T cell dynamics.

Cite This Study

Firoz et al. (2026) studied this question.

synapsesocial.com/papers/6a782d962e1896536c840ded https://doi.org/10.1182/bloodadvances.2025019559

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August 9, 2026Blood AdvancesOpen Access

Chronic xenogeneic GVHD after CAR T cell therapy limits long-term safety assessment of CAR effects using NSG mouse model

View Full Paper

Ask AI

Bookmark

Authors

WFWahed A. Firoz MSMichael K. Sheng PRPedro Ruivo

Discussion

Member takes

Overview

Randomized trial demonstrates chronic xenogeneic GVHD impacts CAR T efficacy assessment in NSG mouse models, indicating a need for caution in interpretation.

Key Points

This research examines the long-term effects of CAR T cell therapy in xenogeneic mouse models, focusing on xenogeneic graft-versus-host disease (xenoGVHD).
Altered donor T cells to memory phenotypes for CAR T generation to assess xenoGVHD effects.
Utilized MHCI/II double-knockout NSG mice to confirm the xenoGVHD pathology was mediated by human TCR murine MHC interactions.
Monitored CAR T cell populations and xenoGVHD outcomes over extended post-transfer periods.
A significant delay in lethal xenoGVHD occurrence was observed, with up to 200 days post-transfer for some donor T cells.
Chronic xenoGVHD was characterized by scleroderma and multi-organ pathology occurring without the presence of B cells.
Emergence of CAR-negative T cell populations during xenoGVHD responses was noted, indicating alterations in T cell dynamics.

Cite This Study

Firoz et al. (2026) studied this question.

synapsesocial.com/papers/6a782d962e1896536c840ded https://doi.org/10.1182/bloodadvances.2025019559

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