Observations identify mismatch repair status affecting clinical staging accuracy in rectal cancer, suggesting improvements for treatment outcomes.
In RC patients treated with upfront surgery or with SCRT followed directly by surgery, pMMR tumours were more prone to clinical understaging, while dMMR tumours were more frequently overstaged. MMR status should be taken into account in clinical staging for better prognosis estimation and appropriate treatment advice.
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Lunenberg et al. (2025) studied this question.
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