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November 19, 2025Food FrontiersOpen Access

Protective Effects of Auricularia auricula Polysaccharides on Acute Lung Injury by Regulating Intestinal Flora and Metabolism

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Authors

HNHaili NiuFZFang-Jia ZhaoQWQi Wang

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Overview

Study demonstrates Auricularia auricula polysaccharides reduce acute lung injury and inflammation in mice, indicating a gut–lung axis role.

Key Points

  • This research aims to explore the protective effects of Auricularia auricula polysaccharides on acute lung injury.
  • Investigation of Auricularia auricula polysaccharides at doses of 100, 200, and 400 mg/kg in mice.
  • LPS-induced acute lung injury model used to assess efficacy against pulmonary edema and protein leakage.
  • Analysis of pro-inflammatory cytokines and antioxidant capacity in lung tissue samples.
  • Auricularia auricula polysaccharides significantly reduced pulmonary edema compared to the LPS group.
  • The polysaccharides dose-dependently suppressed key pro-inflammatory cytokines including TNF-α, IL-1β, and IL-6.
  • Restoration of antioxidant capacity was observed with significant improvements in GSH-Px and SOD levels.

Cite This Study

Niu et al. (2025) studied this question.

synapsesocial.com/papers/6924fee0c0ce034ddc3513d8https://doi.org/10.1002/fft2.70157
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