Breast reconstruction-related complications from postmastectomy radiation therapy in stage II–III breast cancer: sub-analysis of a multi-institutional observational study (Reborn-03)
Observational study shows increased complications in prosthetic breast reconstruction post-Radiation therapy, suggesting careful consideration for patients.
Key Points
To examine complications related to breast reconstruction after postmastectomy radiation therapy in stage II–III breast cancer patients.
Multi-institutional cohort study including breast cancer patients undergoing reconstruction after mastectomy.
Retrospective analysis of complications in immediate and delayed breast reconstruction post-PMRT.
Statistical adjustments made for patient characteristics and type of reconstruction.
Complications occurred in 25.2% of non-PMRT and 31.5% of PMRT patients (p = 0.028).
In prosthetic breast reconstruction, capsule contracture (p < 0.001) and infection (p = 0.014) were significantly higher in PMRT group.
PMRT identified as an independent risk factor for BR-related complications with odds ratio of 1.47 (p = 0.032).